BDBM392443 3,4-dimethyl-N-(2-phenylthiazolo [5,4-b]pyridin-6-yl)-1H-pyrazole-5- carboxamide::US10301280, Compound P-2144

SMILES Cc1n[nH]c(C(=O)Nc2cnc3sc(nc3c2)-c2ccccc2)c1C

InChI Key InChIKey=CKSNDOMNWPWMNX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392443   

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM392443(3,4-dimethyl-N-(2-phenylthiazolo [5,4-b]pyridin-6-...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandPNGBDBM392443(3,4-dimethyl-N-(2-phenylthiazolo [5,4-b]pyridin-6-...)
Affinity DataKi:  5.50E+3nMAssay Description:Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent