BDBM392347 US10301278, Example 30

SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccnc2C(F)(F)F)c(N)n1

InChI Key InChIKey=NOFINDIEOAUEAE-UHFFFAOYSA-N

Data  5 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 392347   

LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50: 66nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50: 67nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50: 339nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50: 142nMAssay Description:Allosteric inhibition of IRS1 peptide-activated human recombinant SHP2 (Met1 to Leu525) expressed in Escherichia coli assessed as inhibition of depho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed