BDBM392326 (4-amino-1-(6-amino-5-((2,3-dichloropyridin-4-yl)thio)pyrazin-2-yl)piperidin-4-yl)methanol::US10301278, Example 52

SMILES Nc1nc(cnc1Sc1ccnc(Cl)c1Cl)N1CCC(N)(CO)CC1

InChI Key InChIKey=WBNAJTSDAUMQLB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392326   

LigandPNGBDBM392326((4-amino-1-(6-amino-5-((2,3-dichloropyridin-4-yl)t...)
Affinity DataIC50: 62nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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