BDBM392325 3-((3-amino-2-chlorophenyl)thio)-6-(4-(aminomethyl)-4-fluoropiperidin-1-yl)pyrazin-2-amine::US10301278, Example 44

SMILES NCC1(F)CCN(CC1)c1cnc(Sc2cccc(N)c2Cl)c(N)n1

InChI Key InChIKey=COHQGLHALGRBTD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392325   

LigandPNGBDBM392325(3-((3-amino-2-chlorophenyl)thio)-6-(4-(aminomethyl...)
Affinity DataIC50: 271nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent