BDBM392324 6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3-dichloropyridin-4-yl)thio)pyrazin-2-amine::US10301278, Example 43::US10301278, Example 49

SMILES CC1(CN)CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=SHTCSCWHCOLKRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392324   

LigandPNGBDBM392324(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...)
Affinity DataIC50: 14nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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LigandPNGBDBM392324(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...)
Affinity DataIC50: 100nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent