BDBM392314 6-(4-(aminomethyl)-4-(pyridin-3-yl)piperidin-1-yl)-3-((2,3-dichlorophenyl)thio)pyrazin-2-amine::US10301278, Example 28

SMILES NCC1(CCN(CC1)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1)c1cccnc1

InChI Key InChIKey=DCVGSEBNXNDGDR-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392314   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis

US Patent

LigandBDBM392314(6-(4-(aminomethyl)-4-(pyridin-3-yl)piperidin-1-yl)...)Copy SMILESCopy InChI

Affinity DataIC50: 54nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/25/2020
Entry Details
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