BDBM392311 N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-3-chloropropanamide::US10301278, Example 16::US10301278, Example 17::US10301278, Example 18::US10301278, Example 3

SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccc(N)c2Cl)c(N)n1

InChI Key InChIKey=WNFIWADQGMQPQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 392311   

LigandPNGBDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 85nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 94nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 66nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 62nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 76nMAssay Description:Inhibition of SHP2 (unknown origin) using DiFMUP as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed