BDBM392309 N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-2-methoxybenzamide::US10301278, Example 12

SMILES COc1ccccc1C(=O)Nc1cccc(Sc2ncc(nc2N)N2CCC(C)(N)CC2)c1Cl

InChI Key InChIKey=QTPVYNYMLNIUBA-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392309   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis

US Patent

LigandBDBM392309(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)Copy SMILESCopy InChI

Affinity DataIC50: 180nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/25/2020
Entry Details
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