BDBM392009 6-(4-amino-4-methylpiperidin-1-yl)-3-((2-(trifluoromethyl)phenyl)thio)pyrazin-2-amine::US10301278, Example 4

SMILES CC1(N)CCN(CC1)c1cnc(Sc2ccccc2C(F)(F)F)c(N)n1

InChI Key InChIKey=QYXCFZQRLROSRX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 392009   

LigandPNGBDBM392009(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-(trifluor...)
Affinity DataIC50: 59nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM392009(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-(trifluor...)
Affinity DataIC50: 178nMAssay Description:Allosteric inhibition of wild-type human SHP2 (1 to 535 residues) using DiFMUP and 2p-IRS1 peptide as substrates preincubated for 1 hr and followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM392009(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-(trifluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Allosteric inhibition of recombinant human SHP2 PTP domain (237 to 535 residues) using DiFMUP as substrate preincubated for 30 mins and followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed