BDBM391825 US10300074, Compd 20::US10300074, Compd 21

SMILES CN[C@@H](C)C(=O)N[C@H]1CCCN(C2CCC(N2C1=O)C(=O)NC1CCCc2ccccc12)C(C)=O

InChI Key InChIKey=GQKHBNWZSAKNGT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391825   

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM391825(US10300074, Compd 21 | US10300074, Compd 20)
Affinity DataKi: <2.50E+4nMAssay Description:5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM391825(US10300074, Compd 21 | US10300074, Compd 20)
Affinity DataKi: <2.50E+4nMAssay Description:5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [1-168]/[124-242](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM391825(US10300074, Compd 21 | US10300074, Compd 20)
Affinity DataKi: >5.00E+4nMAssay Description:5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [1-168]/[124-242](Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM391825(US10300074, Compd 21 | US10300074, Compd 20)
Affinity DataKi: >5.00E+4nMAssay Description:5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent