BDBM391735 N-(6-((2-((4-(1-acetylpiperidin-4-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)pyridin-2-yl)acrylamide ::US10300058, Compound 4

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)n2)n1)C(F)(F)F)C1CCN(CC1)C(C)=O

InChI Key InChIKey=VWKFGMCZHYQJRN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391735   

TargetEpidermal growth factor receptor(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM391735(US10300058, Compound 4 | N-(6-((2-((4-(1-acetylpip...)
Affinity DataIC50: 423nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
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TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM391735(US10300058, Compound 4 | N-(6-((2-((4-(1-acetylpip...)
Affinity DataIC50: 7.20nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent