BDBM391287 1-cyanoethyl 4- (cyanomethyl)-4-(3-((4- (N,N-dimethylsulfamoyl) phenyl)amino)-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)piperidine- 1-carboxylate::US9957264, Example 11-10

SMILES CC(OC(=O)N1CCC(CC#N)(CC1)n1nc(Nc2ccc(cc2)S(=O)(=O)N(C)C)c2c1cc[nH]c2=O)C#N

InChI Key InChIKey=GCNDXXSIOIKPLV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391287   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391287(US9957264, Example 11-10 | 1-cyanoethyl 4- (cyanom...)
Affinity DataIC50: 0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391287(US9957264, Example 11-10 | 1-cyanoethyl 4- (cyanom...)
Affinity DataIC50: 0.100nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent