BDBM391104 US9957264, Example 5-175::[(1R,2R)-2-fluoro-1-{3-[(4- {1-methyl-1-[(1- methylethyl)amino]ethyl} phenyl)amino]-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl} cyclohexyl]acetonitrile (from I-19A)

SMILES CC(C)NC(C)(C)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)[C@@]2(CC#N)CCCC[C@H]2F)cc1

InChI Key InChIKey=IUSHFHFQXQXSQX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391104   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391104(US9957264, Example 5-175 | [(1R,2R)-2-fluoro-1-{3-...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391104(US9957264, Example 5-175 | [(1R,2R)-2-fluoro-1-{3-...)
Affinity DataIC50: 0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent