BDBM391032 (2S,5S)-tert-butyl 5-(3- ((4-(1-amino-2,2,2- trifluoroethyl) phenyl)amino)-4-oxo- 4,5-dihydro-1H- pyrazolo[4,3-c] pyridin-1-yl)-5- (cyanomethyl)tetrahydro- 2H-pyran-2-carboxylate (derived from aryl bromide I-29A and I-14-1A)::US9957264, Example 5-103::US9957264, Example 5-104

SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc(cc2)C(N)C(F)(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=FNWGQOPCFGTWRX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391032   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391032(US9957264, Example 5-104 | (2S,5S)-tert-butyl 5-(3...)
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391032(US9957264, Example 5-104 | (2S,5S)-tert-butyl 5-(3...)
Affinity DataIC50: 0.230nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391032(US9957264, Example 5-104 | (2S,5S)-tert-butyl 5-(3...)
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391032(US9957264, Example 5-104 | (2S,5S)-tert-butyl 5-(3...)
Affinity DataIC50: 0.270nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent