BDBM391024 (2S,5S)-tert-butyl 5- (cyanomethyl)-5-(4- oxo-3-((1-oxo-2-(2,2,2- trifluoroethyl)isoindolin-5- yl)amino)-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)tetrahydro-2H-pyran-2- carboxylate (from I-14-1A)::US9957264, Example 5-95

SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc3C(=O)N(CC(F)(F)F)Cc3c2)c2c1cc[nH]c2=O

InChI Key InChIKey=GJEFXVFPINXVME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391024   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391024(US9957264, Example 5-95 | (2S,5S)-tert-butyl 5- (c...)
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391024(US9957264, Example 5-95 | (2S,5S)-tert-butyl 5- (c...)
Affinity DataIC50: 0.200nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent