BDBM390999 US9957264, Example 5-70::methyl 4-(cyanomethyl)-4- [3-[(2-methyl-1,1-dioxo-2,3- dihydro-1,2-benzothiazol-5- yl)amino]-4-oxo-1H,4H,5H- pyrazolo[4,3-c]pyridin-1- yl]piperidine-1-carboxylate

SMILES COC(=O)N1CCC(CC#N)(CC1)n1nc(Nc2ccc3c(CN(C)S3(=O)=O)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=YNJSNNAMLJBQCZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390999   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390999(US9957264, Example 5-70 | methyl 4-(cyanomethyl)-4...)
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390999(US9957264, Example 5-70 | methyl 4-(cyanomethyl)-4...)
Affinity DataIC50: 0.580nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent