BDBM390731 (R)-N-(3-Aminochroman-7-yl)-3,4-difluorobenzamide::US9957261, Example 87

SMILES N[C@H]1COc2cc(NC(=O)c3ccc(F)c(F)c3)ccc2C1

InChI Key InChIKey=AEVYBPWVWSQLCQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390731   

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM390731(US9957261, Example 87 | (R)-N-(3-Aminochroman-7-yl...)
Affinity DataKi:  0.900nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM390731(US9957261, Example 87 | (R)-N-(3-Aminochroman-7-yl...)
Affinity DataKi:  18.9nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent