BDBM390128 N-{6-Cyano-2-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide::US9951086, Example 20

SMILES CN1CCN(CC1)C(=O)Cn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C#N

InChI Key InChIKey=IOKCIWOKFITZTJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390128   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM390128(N-{6-Cyano-2-[2-(4-methylpiperazin-1-yl)-2-oxoethy...)
Affinity DataIC50: 126nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM390128(N-{6-Cyano-2-[2-(4-methylpiperazin-1-yl)-2-oxoethy...)
Affinity DataIC50: 126nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human IRAK4 expressed in baculovirus infected Hi-5 cells using biotinylated-Ahx-KKARFSRFAGSSPSQASFAEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed