BDBM389611 N'-{6-fluoro-2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-4- yl}-N,N-dimethylethane-1,2-diamine::US9951029, 128

SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3cc(F)ccc3n2)cc1

InChI Key InChIKey=GIVPIMDNDFCLHM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 389611   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389611(US9951029, 128 | N'-{6-fluoro-2-[(E)-2-(4- isoprop...)
Affinity DataIC50: 582nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener ADP Assay FP method (BellBrook Labs, Madison,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389611(US9951029, 128 | N'-{6-fluoro-2-[(E)-2-(4- isoprop...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389611(US9951029, 128 | N'-{6-fluoro-2-[(E)-2-(4- isoprop...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389611(US9951029, 128 | N'-{6-fluoro-2-[(E)-2-(4- isoprop...)
Affinity DataIC50: 190nMAssay Description:Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed