BDBM389560 N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- yl}-N,N-diethylpropane-1,3-diamine::US9951029, 11

SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2ccc(Br)cc12

InChI Key InChIKey=QPWALSGYSNGDJL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 389560   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.96E+3nMAssay Description:FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener ADP Assay FP method (BellBrook Labs, Madison,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vichem Chemie Kutató

US Patent
LigandPNGBDBM389560(US9951029, 11 | N'-{6-bromo-2-[(E)-2-(4- methoxyph...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed