BDBM389161 (R)-3-(6-chloro-5- fluoro-1H-indol-3-yl) pyrrolidine-2,5-dione::US9949951, 8

SMILES Fc1cc2c(c[nH]c2cc1Cl)[C@H]1CC(=O)NC1=O

InChI Key InChIKey=HXMKSWGNEVHRHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389161   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM389161(US9949951, 8 | (R)-3-(6-chloro-5- fluoro-1H-indol-...)
Affinity DataIC50: 3.60E+3nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM389161(US9949951, 8 | (R)-3-(6-chloro-5- fluoro-1H-indol-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed