BDBM389150 3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-5- carbonitrile::US9949951, 14

SMILES O=C1CC(C(=O)N1)c1c[nH]c2ccc(cc12)C#N

InChI Key InChIKey=TUSBRFNYOIATEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389150   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM389150(US9949951, 14 | 3-(2,5-dioxopyrrolidin- 3-yl)-1H-i...)
Affinity DataIC50: 1.20E+4nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM389150(US9949951, 14 | 3-(2,5-dioxopyrrolidin- 3-yl)-1H-i...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed