BDBM388327 US10294246, Compound No. 24

SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1C(F)(F)F

InChI Key InChIKey=IWTHKZODSJLBNE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 388327   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM388327(US10294246, Compound No. 24)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM388327(US10294246, Compound No. 24)
Affinity DataIC50: 2.75E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent