BDBM387290 N-(5- (5,5-Dimethyl-4,5- dihydroisoxazol-3- yl)-2- methylphenyl)pyrazin- 2-yl)-2,6- difluorobenzamide::US10292981, Example 53

SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1

InChI Key InChIKey=DREFJQDUVPJVKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387290   

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387290(US10292981, Example 53 | N-(5- (5,5-Dimethyl-4,5- ...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387290(US10292981, Example 53 | N-(5- (5,5-Dimethyl-4,5- ...)
Affinity DataIC50: 328nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed