BDBM387281 N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2- methylphenyl)pyridin- 2-yl)-2,6- difluorobenzamide ::US10292981, Example 4

SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O

InChI Key InChIKey=BBFUAFQFQUCONY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387281   

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387281(US10292981, Example 4 | N-(5-(5- (5,5-Dimethyl-4-o...)
Affinity DataIC50: 550nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387281(US10292981, Example 4 | N-(5-(5- (5,5-Dimethyl-4-o...)
Affinity DataIC50: 178nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed