BDBM387280 N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- 5-oxo-4,5-dihydro- 1,3,4-oxadiazol-2- yl)phenyl)thiophene- 2-carboxamide::US10292981, Example 176

SMILES Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F

InChI Key InChIKey=RAZCHIWVZLUOQN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387280   

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
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LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Jurkat E6.1 cells were seeded at a density of 1-2×105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
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LigandPNGBDBM387280(US10292981, Example 176 | N-(2,6- Difluorophenyl)-...)
Affinity DataIC50: 500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent