BDBM387269 2- Chloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydroisoxazol-3- yl)-2-methyl phenyl)pyrazin-2-yl)- 6-fluorobenzamide::US10292981, Example 80

SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2Cl)cn1)C1=NOC(C)(C)C1=O

InChI Key InChIKey=KFLVVCARMXCDDZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387269   

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387269(US10292981, Example 80 | 2- Chloro-N-(5-(5-(5,5- d...)
Affinity DataIC50: 100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetInterleukin-2(Human)
Lupin

US Patent
LigandPNGBDBM387269(US10292981, Example 80 | 2- Chloro-N-(5-(5-(5,5- d...)
Affinity DataIC50: 65nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed