BDBM387192 5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-N-ethylhexahydrocyclopenta[c]pyrrole-2(1H)-sulfonamide::US9938257, Example 45

SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)O)c2)ncc1Cl

InChI Key InChIKey=NRTFVVVPFDOHFK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387192   

TargetAurora kinase A(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387192(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Affinity DataIC50: 5nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387192(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Affinity DataIC50: 0.800nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent