BDBM387185 1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[5.5]undecan-9-yl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol::US9938257, Example 37

SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1

InChI Key InChIKey=XVAFGIDSNSLOJM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387185   

TargetTyrosine-protein kinase JAK1(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387185(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Affinity DataIC50: 2nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387185(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Affinity DataIC50: 71nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387185(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Affinity DataIC50: 131nMAssay Description:JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent