BDBM387182 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-N-ethylhexahydrocyclopenta[c]pyrrole-2(1H)-sulfonamide::US9938257, Example 24

SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl

InChI Key InChIKey=NGEVHWVGFQLFEK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387182   

TargetTyrosine-protein kinase JAK1(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387182(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50: 2nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387182(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50: 3nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387182(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50: 0.700nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent