BDBM387177 US9938257, Example 15::ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl

InChI Key InChIKey=SBJRRILZYCCWJE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 387177   

TargetTyrosine-protein kinase JAK1(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387177(ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)am...)
Affinity DataIC50: 8nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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TargetAurora kinase A(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387177(ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)am...)
Affinity DataIC50: 10nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387177(ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)am...)
Affinity DataIC50: 136nMAssay Description:JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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TargetAurora kinase B(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387177(ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)am...)
Affinity DataIC50: 2nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Calitor Sciences

US Patent
LigandPNGBDBM387177(ethyl 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)am...)
Affinity DataIC50: 503nMAssay Description:FLT3:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent