BDBM387036 2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-acetamide::US9938265, Example 23::US9938265, Example 24

SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)c(OC)c1

InChI Key InChIKey=UIPMTIIMXUDEQN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387036   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387036(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Affinity DataIC50: 265nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387036(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Affinity DataIC50: 71.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent