BDBM387025 (2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-2-phenyl-acetamide::US9938265, Example 12

SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(Cl)cnn2)s1)c1ccccc1

InChI Key InChIKey=MSKIYGPTRXMYOV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387025   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387025((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 35.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

LigandPNGBDBM387025((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed