BDBM387013 (2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US9938265, Example 6(a)

SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)c(OC)c1

InChI Key InChIKey=QFAHGXFMNKFWKL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 387013   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Astrazeneca

US Patent
LigandPNGBDBM387013((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Affinity DataIC50: 82.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent