BDBM386774 (2S,4R)-1-(2-(3- acetyl-5-(2- (hydroxymethyl) pyrimidin-5-yl)- 1H-indazol-1- yl)acetyl)-N-(6- bromopyridin-2- yl)-4-fluoro-N- methylpyrrolidine- 2-carboxamide::US10287301, Compound 737::US10822352, Comp No. 737

SMILES CN(C(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(C)=O)c2cc(ccc12)-c1cnc(CO)nc1)c1cccc(Br)n1

InChI Key InChIKey=JVKJYKVQARAEMI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386774   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386774((2S,4R)-1-(2-(3- acetyl-5-(2- (hydroxymethyl) pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386774((2S,4R)-1-(2-(3- acetyl-5-(2- (hydroxymethyl) pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent