BDBM386100 N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-1- (pyrrolidin-1-ylcarbonyl)piperidin- 3-yl)methanesulfonamide::US10287305, Example 39::US10508083, Example 39::US11292766, Example 39

SMILES CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)N1CCCC1)NS(C)(=O)=O

InChI Key InChIKey=MRAXJCWWMJBFHA-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386100   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386100(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  940nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386100(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  940nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386100(N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)...)
Affinity DataEC50:  940nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent