BDBM386067 US10287305, Example 5::US10508083, Example 191::US11292766, Example 191::methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxylate

SMILES COC(=O)N1CCC[C@@H]([C@@H]1COC2CCC(CC2)c3ccccc3)NS(=O)(=O)C

InChI Key InChIKey=UXZAJSZFFARTEI-UHFFFAOYSA-N

Data  12 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 386067   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX1R stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  5.50E+3nMAssay Description:Agonist activity at human OX2R stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells assessed as increase in calcium mobilization by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at OX1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at OX2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed