BDBM386047 4-(4-(1-(3,4-difluorophenyl)-2-(methylamino)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one::US10287300, Compound A50

SMILES CNCC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(F)c(F)c1

InChI Key InChIKey=NKJPGYHWNSLBEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386047   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM386047(4-(4-(1-(3,4-difluorophenyl)-2-(methylamino)ethyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandPNGBDBM386047(4-(4-(1-(3,4-difluorophenyl)-2-(methylamino)ethyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent