BDBM386022 4-{4-[2-dimethylamino-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-7,8-dihydro-5H-pteridin-6-one::US10287300, Compound A28

SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=LCYFZKPOQLPRKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386022   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM386022(4-{4-[2-dimethylamino-1-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandPNGBDBM386022(4-{4-[2-dimethylamino-1-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50: 300nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent