BDBM386015 US10287300, Compound A21::[2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-ethyl]-dimethylamine

SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=BRCQOPRRHNTMQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386015   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM386015([2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandPNGBDBM386015([2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent