BDBM386008 2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-2-(4-fluorophenyl)-ethylamine::US10287300, Compound A14

SMILES NCC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(F)cc1

InChI Key InChIKey=TZBUQVAGXZCMNE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386008   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM386008(2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50: 750nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetProline-rich AKT1 substrate 1(Human)
Merck Patent

US Patent
LigandPNGBDBM386008(2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50: 750nMAssay Description:A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent