BDBM385987 (R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4-(1- methylcyclopropyl) phenyl)ethyl)imidazo [5,1-f][1,2,4]triazin- 4(3H)-one::US10287293, Example 36::US10287293, Example 37

SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C1(C)CC1

InChI Key InChIKey=KRHNLWXBBWWRAF-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385987   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385987(US10287293, Example 36 | (R)- or (S)-5- (hydroxyme...)
Affinity DataKi:  0.400nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385987(US10287293, Example 36 | (R)- or (S)-5- (hydroxyme...)
Affinity DataKi:  109nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent