BDBM385981 (R)- or (S)-7-(1-(2- fluoro-4- (trifluoromethyl) phenyl)ethyl)-5- (hydroxymethyl)-2- methylimidazo[5,1- f][1,2,4]triazin- 4(3H)-one::US10287293, Example 30::US10287293, Example 31

SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=XIOWTFPESNIMML-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385981   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385981(US10287293, Example 30 | (R)- or (S)-7-(1-(2- fluo...)
Affinity DataKi:  0.800nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385981(US10287293, Example 30 | (R)- or (S)-7-(1-(2- fluo...)
Affinity DataKi:  200nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent