BDBM385966 (R)- or (S)-3- (1-(4- (tert- Butyl) phenyl) ethyl)- 1-(2- fluoro- ethyl)- 5- methyl- 1,6- dihydro- 7H- pyrazolo [4,3-d] pyrimi- din-7-one::US10287293, Example 15::US10287293, Example 16

SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=BJQIRHYYUPTLHG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385966   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385966(US10287293, Example 15 | US10287293, Example 16 | ...)
Affinity DataKi:  1.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385966(US10287293, Example 15 | US10287293, Example 16 | ...)
Affinity DataKi:  82.9nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent