BDBM385535 (1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (trifluoromethyl)cyclo- propyl)benzoyl)-6- (2-oxa-6- azaspiro[3.4]octane- 6-carbonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl)-6- methylcyclohex-3- ene-1-carboxylic acid::US10287272, Example 17G::US10689369, Example 17G

SMILES C[C@H]1CC(=CC[C@H]1C(O)=O)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)N1CCC2(COC2)C1

InChI Key InChIKey=BWFDTUAJGATQEF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385535   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385535((1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (...)
Affinity DataIC50: 1nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385535((1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (...)
Affinity DataIC50: 1nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent