BDBM385388 (E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]pyrimidin-5-yl]oxymethyl]prop-2-en-1-amine::US10287270, Example 5::US10464928, Example 5::US10793552, Example 5::WO2018/027892, Example 5

SMILES CO[C@H]1CCN(C1)c1ncc(OC\C(CN)=C\F)cn1

InChI Key InChIKey=JXYUYCVRGOBMGR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 385388   

TargetAmine oxidase [copper-containing] 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 32nMAssay Description:Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo assay kit from Promega (V1402). Test compounds (wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 32nMAssay Description:Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo assay kit from Promega (V1402). Test compounds (wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 32nMAssay Description:Amine oxidase activity of recombinant SSAO, MAOa, and MAOb isoforms are measured using the MAO-Glo assay kit from Promega (V1402). Test compounds (wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 13nMAssay Description:For the determination of AOC3 activity or compound inhibition potency, the compound inhibitors are dissolved in DMSO and adjusted to the respective a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetAmine oxidase [copper-containing] 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 497nMAssay Description:An AOC2 enzyme containing cell homogenate is generated by transient transfection of 6×106 HEK293 cells per flask (T75) with 9 μg pCMV-SPORT6-AOC2 (BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
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TargetDiamine oxidase [copper-containing](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM385388((E)-3-Fluoro-2-[[2-[(3S)-3-methoxypyrrolidin-1-yl]...)
Affinity DataIC50: 268nMAssay Description:For the determination of AOC1 activity or compound AOC1 inhibition potency, the compound inhibitors are dissolved in DMSO and adjusted to the respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent