BDBM385386 US10287268, Compound I-4::US10975058, Compound I-4

SMILES Cc1cccc(Cl)c1Nc1nccn1-c1cc(Nc2cnn(C)c2)ncn1

InChI Key InChIKey=WTXIDZJDPGBCIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 385386   

TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM385386(US10287268, Compound I-4 | US10975058, Compound I-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In some experiments, inhibitory activities of the compounds described herein against select protein kinases were determined as IC50 values (e.g., IC5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase HCK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM385386(US10287268, Compound I-4 | US10975058, Compound I-...)
Affinity DataIC50: 3.00E+3nMAssay Description:In some experiments, inhibitory activities of the compounds described herein against select protein kinases were determined as IC50 values (e.g., IC5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM385386(US10287268, Compound I-4 | US10975058, Compound I-...)
Affinity DataIC50: 1.00E+4nMAssay Description:This buffer consisted of 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 1 mg ml−1 bovine serum albumin and 0.1% (vol/vol) 2-mercaptoethanol.10× Concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase HCK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM385386(US10287268, Compound I-4 | US10975058, Compound I-...)
Affinity DataIC50: 3.00E+3nMAssay Description:This buffer consisted of 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 1 mg ml−1 bovine serum albumin and 0.1% (vol/vol) 2-mercaptoethanol.10× Concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent