BDBM385075 US10287258, Example 35::US10669245, Example 35::US11117874, Example 35::US11673871, Example 35::US11680049, Example 35::US20230278969, Example 35

SMILES CN1C(=O)CNc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1

InChI Key InChIKey=CPBDCTBYFQTDMV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 385075   

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385075(US10287258, Example 35 | US10669245, Example 35 | ...)
Affinity DataIC50: 24.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent