BDBM385074 US10287258, Example 34::US10669245, Example 34::US11117874, Example 34::US11667615, Example 34::US11680049, Example 34

SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)C1CNCCCO1

InChI Key InChIKey=FCRODBUNBQJNPU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 385074   

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50: 60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50: 60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50: 60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50: 60.3nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385074(US10287258, Example 34 | US10669245, Example 34 | ...)
Affinity DataIC50: 60.3nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent