BDBM385062 (2S)-N-{(1S)-1-Cyano-2-[4-(5-cyanothiophen-2-yl)phenyl]ethyl}-1,4-oxazepane-2- carboxamide::US10287258, Example 22::US10669245, Example 22::US11117874, Example 22::US11655221, Example 22::US11667615, Example 22::US11680049, Example 22::US20230278969, Example 22

SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(s1)C#N)C#N)[C@@H]1CNCCCO1

InChI Key InChIKey=AYKAKRZDQIFHMD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 385062   

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385062(US11667615, Example 22 | US11117874, Example 22 | ...)
Affinity DataIC50: 19.5nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent